Changes of leptin resistance, blood lipids and inflammatory response before and after the exercise therapy in children with obesity / 中国当代儿科杂志

<p><b>OBJECTIVE</b>Some research has shown that C-reactive protein (CRP), leptin, soluble leptin receptor (sLR) and blood lipids are involved in the development of obesity. This study aimed to investigate the changes of leptin resistance, blood lipids and inflammatory response before and after the exercise therapy in children with obesity.</p><p><b>METHODS</b>Fifty-one obese children at ages of 12 years received an exercise therapy for 2 months. The levels of serum leptin, sLR, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) were measured before and after the exercise therapy. Forty normal children served as the control group.</p><p><b>RESULTS</b>Compared with the control group, serum levels of leptin, TG, TC, LDL-C and hs-CRP and the body mass index (BMI) in the obese group increased (p<0.01), while the serum level of sLR decreased significantly (p<0.05). The levels of hs-CRP, leptin, TC, TG, LDL-C and BMI in the obese group were significantly reduced after the exercise therapy (p<0.05). In the obese group, the serum leptin level was positively correlated with the levels of blood lipids and hs-CRP (p<0.05); serum levels of leptin and hs-CRP were negatively correlated with the sLR level (p<0.05); the hs-CRP level was positively correlated with the levels of blood lipids (p<0.01).</p><p><b>CONCLUSIONS</b>Leptin resistance and the changes of blood lipids and inflammatory response are found in children with obesity. Exercise therapy can partially improve these changes.</p>

Metalloproteinases and disintergrins of snake venom: Structures and functions / 第二军医大学学报

Snake venom metalloproteinase is one of the main function proteins in snake venom. It directly affects the interactions between capillary endothelium cells and basement membrane in local tissues. Snake venom disintegrin and metalloproteinase are derived from the same pre-pro-metalloproteinase, which contains 4 common structural domains: Pre-domain, Pro-domain, Proteinase domains, and Spacer region. Disintegrin, a low molecular weight protein containing several Cys residues, can block the binding of integrins and their ligands and inhibit adhering reaction(cell to cell and cell to extracellular matrix) mediated by integrin. It also plays a significant role in platelet aggregation, infection, inflammation reaction, tumor metastasis, etc..

Evaluation of the effect of interventions for the female drug abusers / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To investigate an effective method to facilitate the physical and mental recovery of drug abusers in detoxification restoration period.</p><p><b>METHODS</b>Integrated interventions were adopted to observe the changes in the physical and mental conditions of female drug abusers who had withdrawn drugs.</p><p><b>RESULTS</b>Comparing behavioral changes between the two groups before and after intervention, we found that changes of score in the intervention group were all higher than those in the control group in terms of their physical symptoms or state of anxiety.</p><p><b>CONCLUSION</b>It is necessary to help drug abusers understand the harm of drug-abuse, build up self-confidence and improve EQ through interventions. It will be beneficial for the drug addicts to refrain from drug-taking and regain a normal life. Our study has proved that positive results can only be obtained from integrated intervention projects.</p>